Science & Technology

Associate Director – DMPK

Not Specified

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

*Job Summary*

As part of our continued success, we have an exciting opportunity for an experienced leader to join our multi-disciplinary team as Associate Director, DMPK at our Cambridge site in the UK. The successful candidate will have demonstrated DMPK scientific and strategic leadership skills, be an excellent collaborator through effective interactions with colleagues across disciplines, across Charles River companies and with existing and potential clients.

You will be influential within DMPK and be a positive role model across disciplines, and someone who proactively manages the performance and development of direct and indirect reports. There will also be the opportunity for the successful candidate to lead and evolve how we provide in vivo support (e.g. PK, PK/PD, efficacy, early toxicity studies) to our client projects in collaboration with other Charles River companies.

*Main responsibilities *

• To provide managerial, operational and scientific leadership within the DMPK department, with responsibility for performance management, objective setting and providing feedback in a matrix management environment.

• To coach and motivate the team whilst mentoring across disciplines.

• To define operational best practice for discovery in vivo support to client projects through collaboration with other Charles River companies performing the studies and DMPK, Biology and Chemistry Discovery project leads using the data to make decisions.

• To provide ADME/DMPK expertise, including PK/PD and dose to man predictions, to drug discovery projects and innovate to help define project strategy and deliver on agreed project objectives. To help develop others to perform this role.

• To successfully troubleshoot scientific and business related issues.

• To collaborate with colleagues in Business Development to prepare proposals and present to potential new clients. Promote high scientific visibility of CRL Discovery capabilities within CRL and externally.

• To be a positive role model and value the importance of maintaining a positive workplace culture through empowering and engaging staff.

• To ensure resources and finances are managed appropriately.

*Profile and Requirements*

• Extensive DMPK based experience in an industrial drug discovery setting with a proven track record in advancing discovery projects to pre-clinical development.

• Broad experience of the management, mentoring and scientific direction of scientists ideally in a matrix environment.

• Extensive experience in all aspects of modern- day approaches used in DMPK covering in vitro, in vivo and computational tools used to support drug discovery projects.

• Exceptional problem-solving skills, sound scientific, operational and financial judgement and high-quality decision making, which impacts positively on company deliverable.

• Background in working closely with colleagues in chemistry, biology, in vivo DMPK and pharmacology units.

• Ability to communicate confidently with partners/colleagues via teleconferences, presentations and written reports.

• A dynamic and flexible approach towards achieving partner-based objectives and meeting challenging deadlines.

• Experience of identifying and implementing process change, including demonstration of the people skills required to enact change management.

• Models the Charles River Values of Care, Lead, Own and Collaborate.

• As a people leader there is a requirement for you to have an onsite presence (Chesterford Park, Saffron Walden, near Cambridge, UK) for a proportion of your working week. Hybrid and flexible working options that work for you can be discussed.

*In return, you will have the opportunity to: *

• Be part of a multi-disciplinary team who are dedicated to partnering with our clients to discover quality candidate molecules

• Supportive of each other every step of the way

• Work in our modern laboratories based on a countryside science park close to Cambridge city Center.

• A total reward package that includes the opportunity for hybrid and flexible working, generous company pension contributions and the option for private medical and dental insurance. Full relocation assistance is available for the right candidate.

About Discovery

Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.